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A patient with Sneddon's syndrome and 12 available family members belonging to three generations were evaluated to determine the presence of antiphospholipid antibodies(lupus anticoagulant and anticardiolipid antibodies)during vascular thrombotic events and symptomatic periods.Our results support a temporal relation between thrombotic events in Sneddon's syndrome and lupus anticoagulant;anticardiolipin antibodies remained invariable.Our index case patient and her father could be diagnosed as having primary antiphospholipid antibody syndrome.Aspirin was not effective in preventing thrombosis.After the onset of oral anticoagulant therapy,no recurrences were seen.The use of a mixture of phospholipids as antigen could present some advantages in serological studies performed in antiphospholipid syndromes. |
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